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57 Milk thistle

Research has shown that isoflavones and flavonoids of BP restrain the cell cycle at G1 and or G2/M stages and upregulate the expression of pro-apoptotic genes and dysfunction of the capability of enzymes associated with the growth and development of tumor cells while hindering the activity of intermediates such as fibroblast growth factor (FGF) and vascular endothelial growth factor (VEGF) and also inhibiting the production of ROS (177, 178)

As highlighted in this review, the individual cell types in the endometrium (stromal, epithelial, vascular, immune and stem) are subject to the forces of aging and senescence

Luciferase reporter assay A luciferase reporter assay was assessed as previously described with modifications [17]